The 25th Legislative District is home to more than 136,000 Marylanders that reside in the incorporated City of District Heights and Town of Morningside as well as the unincorporated areas of Brock Hall, Capitol Heights, Clinton, Forestville, Hillcrest-Marlow Heights, Joint Base Andrews, Kettering, Largo, Mitchellville, Suitland, Temple Hills, Upper Marlboro, Walker Mill, and Westphalia.

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Notable government-supported facilities within the district include the United States' Joint Base Andrews and Prince George's County Vet Center; the Downtown Largo WMATA Metro Station; the University of Maryland Capital Region Medical Center; the Maryland State Police's Barrack L - Forestville; the Maryland Motor Vehicle Administration - Largo Branch; the Prince George's Community College - Largo Campus and Westphalia Training Center; the Prince George's County Memorial Library System's Largo-Kettering, Spauldings, and Surratts-Clinton Branches; both Watkins and Walker Mill Regional Parks and Marlow Heights, North Forestville, Stephen Decatur, Suitland, Westphalia, and William Beanes Community Centers; the Prince George's County Police Department's District VIII - Westphalia location; the Prince George's County Correctional Center; the Prince George's County Fire/EMS Department Stations 802 - Shady Glen, 823 - Forestville, 825 - Clinton, 827 - Morningside, 837 - Ritchie, and 846 - Largo; and the following Prince George's County Public Schools:

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Elementary/Early Childcare Center: Arrowhead, Barack Obama, Clinton Grove, District Heights, Francis T. Evans, H. Winship Wheatley, James Ryder Randall, John Bayne, Kettering, Kingsford, Longfields, North Forestville, William Beanes; Middle/Specialty/Public Charter: Andrew Jackson, Benjamin Foulois, Benjamin Stoddert, Imagine Foundations at Andrews, Imagine Foundations at Leeland, Imagine Foundations at Morningside, Imagine Lincoln, Kettering, Samuel P. Massie, Stephen Decatur, Walker Mill; High: Academy of Health Sciences; Dr. Henry A. Wise, Jr.; Incarcerated Youth Center; International High School at Largo; Largo; Surrattsville.